[aditi_z]

Dear Daveyo,
My 5 month old pup has been diagnosed with distemper The vet says that there isn't any known absolute cure for the disease. However, you've been putting up posts saying that there is a cure. My puppy hasn't yet begun to show any nervous symptoms but the distemper is confirmed. I looked for the NDV vaccine (La Sota strain) as you have suggested, but the trouble is that it comes in a powder form. I need to know from you the exact diluent and the weight / volume strength of the vaccine to be given. I also need to know the exact quantity to be given to the pup in terms of body weight. In your previous posts you have written 1 pound being equivalent to 2.2 kgs...when it is actually the other way around, 1kg is equal to 2.2 pounds. So, i'm quite confused...and i desperately need your help to save my puppy.
Please help asap Daveyo !

Aditi

[Daveyo]

Ok take an easy here. The powder form is actually a freeze dried form and usually it comes with a sterile solution. I have no idea how long your dog has been infected, but I need to tell you that if your past day 6 from initial onset of symptoms you also will need to do the CSF tap because the virus breaches the blood brain barrier from day 7 all the way till that dog dies.

Now you need to do the body first. Formula is 0.1cc for every pound or 0.45kg. Yes I am aware of the typo error concerning kg vs pound. Each vial of NDV can hold almost 3.0cc which is good for a 30 pound dog or 13.60kg. 10 pounds is 1.0cc or 4.5kg. OK. If between the weights add another 0.1cc of NDV.

You must get the VET to inject into the blood vein of the dog preferred the front leg after you shave off the hair a bit to see it. Put the required amount into the syringe. What you do is take the sterile solution first and fill up the syringe with the correct amount based on the weight forumula. Then take that syringe to the NDV vial and fill that up. Shake it a bit and then draw all of it out into the syringe. From there to the blood vein of the dog.

If you are past day 6, you also have to do the CSF tap. This is based on the size of the dog. A toy dog will get 0.1cc of NDV, a small dog will get 0.2cc, and so on all the way up to the giant size which that amount is 0.5cc of NDV.

Assuming that your dog is a small size since you have not describe what kind of dog you have, the VET needs to do some preps first. The dog needs to be on I.V., the dog needs to get Anti-shock meds prior to do the tap and the VET knows the correct amount, you need a cather, 2 syringes, of which one is for the tap and mixing the NDV into the spinal fluid in the syringe and the other for 0.1cc of saline, also needs anesthesia and the VET needs to shave the back part of the head at the foramen Magnum. Once the dog is sleeping and will not move then you do the tap.

small dog will have 0.5cc of spinal fluid taken out, then the VET discards or saves into another vial for testing later of 0.3cc, then goes to the NDV vial and takes out 0.2cc into the same syringe containing the spinal fluid, and mix it a bit, remove any air in the syringe and needle, and then insert this into the cather that is still on the dog and inject. Once done then take the saline and flush out the needle hub and surgery is finished. Keep the I.V going until the dog wakes up, and let it get up on its own. When it stands up, you can take it home.

The cure for both procedures is 24 hours average. Earliest is 12 hours and the latest is 48 hours.

You also have to treat for pneumonia for 7 days straight and give baytril of 0.5cc and penicillin G of 1.0cc combined and inject intramuscular twice a day or every 12 hours.

By day 7 your dog will have no more pneumonia, and no more Canine Distemper both in the body and in the CNS>

From this point on DO NOT VACCINATE THIS DOG FOR A MINIMUM OF 1 YEAR of any Parvovirus or Distemper vaccines. As to the other vaccines wait minimum of 90 days or more and you can finish up the vaccine program of giving single shots of KILLED VIRUS ONLY. Nothing is to be combined to a post distemper animal.

As of distemper vaccine, your dog is immuned for life against this disease. As of Parvovirus vaccine, you give after 1 year from CSF tap, and only in killed virus form of only 1/2 dose shot spread of 30 days apart. Do not give more than 1 dose of Parvovirus vaccine at one time. Give only 1/2 dose every 30 days for only 1 dose. Then wait 2 months and then you can give the final vaccine dose of same and then leave it alone for the next 3 years. MAKE SURE YOUR PARVO VACCINE IS OF KILLED VIRUS ONLY. UNDER NO CIRCUMSTANCES DOES YOUR DOG GET MODIFIED LIVE OR RECOMBITANT VACCINES. If you do, you will cause a immune cascade problem inside the CNS.

ANY NDV GIVEN EITHER FOR THE BODY AND OR THE CSF CAN ONLY BE GIVEN ONE TIME. That is it. Any further NDV to the same dog you probably will definitely cause a complete immune cascade problem which will kill that dog.

Making the serum takes too much time. USE the NDV which is fast and quick

If all goes right, and you do as instructed, and that your VET follows also as instructed, you will have a dog free of distemper for life and healthy as can be. Your dog will be fully cured in 24 hours of the disease itself both of body and in the CNS if you did the CSF tap as I told you if your past day 6 from onset of symptoms of canine distemper,but pneumonia takes 7 days to get cured of that as well. After that your dog probably will live 10, 15, or 20 years depending on the breed. If your inside day 6 from onset of symptoms, you do not need to do the CSF tap if you give that dog the NDV in the body. Remember this virus will only breach and enter the CNS beginning day 7 from onset of symptoms all the way to when the dog will expire which is by 30-35 days from onset if never given NDV. Once the virus enters the CNS the real damage begins and surely this damage is horrific indeed. If you give the NDV after it breached, the NDV will kill off the virus and your dog will live and be saved, but it will not fix the damage caused by the virus. Only the dog and its genetics and ability to recover can fix the damage themselves. This can be a long term recovery process and that is why I said minimum of 1 year from the tap. The real exposure of the actual damage will appear within 30 days from that NDV tap. At about 45 days from that tap, then the dog will begin to recover and repair it themselves because at this point of time the immune system has recovered from the incredible shock caused by the virus itself and from the incredible speed of NDV making the cytokines which kills this virus in record time, and also the NDV shuts down the deadly C4 T cells which was triggered by the virus which was causing all the destruction thus allowing the time needed for the dog to recover.

Giant breeds have the shortest life span. Toy dogs have the longest lifespan.

Yes the cure is guaranteed if your VET does the instructions properly.

Daveyo

[aditi_z]

Dear Daveyo,
Thank you so much for your response. My dog is a 5 month old stray Indian mongrel puppy weighing 9 kgs.
Now, the trouble with the NDV that i have is that it has come with a sterile diluent (reddish colored liquid) but it says that it is to be used for intra ocular, intra nasal or oral use only. The diluent is in an 18 ml bottle that says " for reconstituting 500 doses". It also says that this is the only diluent recommended with this vaccine. This is what has me confused. Am I to use this same diluent to inject into my puppy..?? If possible, could you let me know an approximate chemical name / composition of the diluent you are referring to.
Also i need to know just what the weight by volume strength of the injection should be. I'm having a little trouble understanding whether 0.1cc by weight of the NDV powder has to be utilized or is it 0.1cc of the NDV and diluent solution that has to be utilized...?
My dog has been showing symptoms for the past 4 days , so i really don't have too much time left..!!
Please do respond and help me save my dog..

Thanks
Aditi

[Daveyo]

Ok I will be on line for the next 9 hours.

First make sure the NDV says Newcastles Disease Virus Vaccine and that it is the LaSorta Strain. Inside this vial it will look like a round freeze dried tablet if you want to call it descriptive wise and when kept cold it will look like white ice inside. The Sterile solution is sterile solution. Any VET has this to mix vaccines. The solution is like water/saline. It has no color.

MAKE SURE YOU KEEP THAT NDV COLD AT ALL TIMES UNTIL TIME OF INJECTION.!!!!!!!!!

So I don't know what you have there, but make sure it is the clear sterile solution. Run to the VET immediately, if you have the NDV in your hands. Tell him you need the sterile solution to mix with the NDV with the required amount and then to inject to your dog. I am sure the VET will comply and help you out. The solution bottle is about twice the size of the NDV vial.

There is no confusion concerning dose here. When you take the sterile diluent (the clear one), you draw this into the syringe. Example >say your dog weighs 9kgs. This is 19.84 pounds. Remember 0.1cc for every pound or 0.45kg OK So add this up. 10 pounds or 4.53kg will require 1.0cc. For the next 9.84 pounds or 4.46kg, you add for each pound 0.1cc. This comes out to another 0.9cc of NDV. Now since you are in between the weights, add 1 more 0.1cc to this total. This comes out to a 20 pound dog or 9.07kg. Understand. So your total amount of NDV you will need is exactly 2.0cc of NDV period.

Now you have the sterile solution. Take out 2.0cc of this solution into the syringe. Then take that syringe and inject this into the NDV vial. Then shake it a bit and then withdraw all of its contents back into that syringe. Then clear all air in this syringe. Done. I suggest your also get another syringe to take out some blood of the animal about 1.0cc prior to the NDV injection and put into another sterile sealed vial to get the WBC count tested at a lab. Most important. You want to know what the WBC level is, of which tells you how well the dog's immune system is holding up since the virus also attacks the bone marrow. Now go to the dog and find the blood vein and then insert the syringe (having the NDV) into the vein. Pull back on the plunger a bit to make sure you see blood going into this syringe. If you do, then inject all of the syringe contents into the dog. Then sterilize the puncture wound. Then your finished for the body.

If you get this in on time in the next 24 hours you probably will make it before the virus enters the CNS. You will be borderline. This dog will be cured in the body itself in 24 hours.

If that dog is starting to have labor breathing then that virus is definitely inside the lung area getting ready to breach the blood brain barrier to enter the CNS. Your going to be awful close time wise.

I will need for you to precisely tell me how the dog has responded every 12 hours for the next 2 days most important. After you do this body injection, then make sure you start the Baytril and penicillin G combo injecting to this dog twice a day every 12 hours for 7 days straight. Definitely your dog has pneumonia which is one of the main characteristics of this disease.

If you do all this immediately above, next 24 hours, the only thing I can say is the odds of the virus breaching the CNS is about 30 -40%. You will be almost the 50 - 50 deal. Remember from day 7 on from onset of symptoms, that virus will breach the CNS. If I were you I would still do the NDV - CSF tap to be on the safe side to cover all the bases. It will not harm the dog at all, and if no virus is inside there, your ahead of the game. If the virus did breached, your still ahead of the game and killing this virus before it really does a lot of damage inside the CNS, because you caught it at the very early stage. I would not take any chances regarding this virus. It is very potent and VERY SMART and it can do a few tricks to you. I know this virus so well I practically can sleep and know what it does to animals.

Ok so get on it right now and get this NDV into the body pronto. Make sure its NDV of the LaSorta strain and the diluent is clear sterile solution.

So make sure you got 2 vials of NDV. One for the body injection and 1 for the CNS injection.

Stay in touch.

Daveyo